Histone H2B type 1-B (H2BC3)

About Histone H2B type 1-B

Histone H2B type 1-B (H2BC3) is a protein from Homo sapiens identified by UniProt accession P33778, 126 residues long. MolForge cross-references it against 0 known binders and 66 disease associations.

Target properties

Protein name	Histone H2B type 1-B
UniProt accession	P33778
Gene	H2BC3
Organism	Homo sapiens
Length	126 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (66)

Diseases linked to this target (Open Targets).

viral disease · score 0.50
infectious disease · score 0.50
breast carcinoma · score 0.38
cancer · score 0.37
melanoma · score 0.37
smoking status measurement · score 0.15
diastolic blood pressure · score 0.14
systolic blood pressure · score 0.13
Red cell distribution width · score 0.09
mean reticulocyte volume · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P33778-F1	alphafold	PREDICTED	88.10	—

Amino-acid sequence (126 residues)

MPEPSKSAPA PKKGSKKAIT KAQKKDGKKR KRSRKESYSI YVYKVLKQVH PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT KYTSSK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards