About ATP-binding cassette sub-family D member 1
ATP-binding cassette sub-family D member 1 (ABCD1) is a protein
from Homo sapiens identified by UniProt accession
P33897, 745 residues long.
MolForge cross-references it against 0 known binders and
265 disease associations.
Target properties
| Protein name | ATP-binding cassette sub-family D member 1 |
|---|
| UniProt accession | P33897 |
|---|
| Gene | ABCD1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 745 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (265)
Diseases linked to this target (Open Targets).
- adrenoleukodystrophy · score 0.87
- X-linked adrenoleukodystrophy · score 0.81
- genetic disorder · score 0.54
- hereditary spastic paraplegia · score 0.53
- Spastic paraparesis · score 0.53
- X-linked cerebral adrenoleukodystrophy · score 0.44
- neurodegenerative disease · score 0.44
- chronic primary adrenal insufficiency · score 0.42
- X-linked spondyloepimetaphyseal dysplasia · score 0.42
- adrenomyeloneuropathy · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P33897-F1 | alphafold | PREDICTED | 80.61 | — |
Amino-acid sequence (745 residues)
MPVLSRPRPW RGNTLKRTAV LLALAAYGAH KVYPLVRQCL APARGLQAPA GEPTQEASGV AAAKAGMNRV FLQRLLWLLR LLFPRVLCRE TGLLALHSAA LVSRTFLSVY VARLDGRLAR CIVRKDPRAF GWQLLQWLLI ALPATFVNSA IRYLEGQLAL SFRSRLVAHA YRLYFSQQTY YRVSNMDGRL RNPDQSLTED VVAFAASVAH LYSNLTKPLL DVAVTSYTLL RAARSRGAGT AWPSAIAGLV VFLTANVLRA FSPKFGELVA EEARRKGELR YMHSRVVANS EEIAFYGGHE VELALLQRSY QDLASQINLI LLERLWYVML EQFLMKYVWS ASGLLMVAVP IITATGYSES DAEAVKKAAL EKKEEELVSE RTEAFTIARN LLTAAADAIE RIMSSYKEVT ELAGYTARVH EMFQVFEDVQ RCHFKRPREL EDAQAGSGTI GRSGVRVEGP LKIRGQVVDV EQGIICENIP IVTPSGEVVV ASLNIRVEEG MHLLITGPNG CGKSSLFRIL GGLWPTYGGV LYKPPPQRMF YIPQRPYMSV GSLRDQVIYP DSVEDMQRKG YSEQDLEAIL DVVHLHHILQ REGGWEAMCD WKDVLSGGEK QRIGMARMFY HRPKYALLDE CTSAVSIDVE GKIFQAAKDA GIALLSITHR PSLWKYHTHL LQFDGEGGWK FEKLDSAARL SLTEEKQRLE QQLAGIPKMQ RRLQELCQIL GEAVAPAHVP APSPQGPGGL QGAST
Explore ATP-binding cassette sub-family D member 1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets