About Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (MAN1A1) is a protein
from Homo sapiens identified by UniProt accession
P33908, 653 residues long.
MolForge cross-references it against 0 known binders and
68 disease associations.
Target properties
| Protein name | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA |
|---|
| UniProt accession | P33908 |
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| Gene | MAN1A1 |
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| Organism | Homo sapiens |
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| Length | 653 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (68)
Diseases linked to this target (Open Targets).
- body mass index · score 0.40
- body fat percentage · score 0.36
- lean body mass · score 0.34
- protein measurement · score 0.34
- blood protein measurement · score 0.33
- fat body mass · score 0.30
- Alzheimer disease · score 0.25
- neurodegenerative disease · score 0.25
- lysosomal storage disease · score 0.25
- Parkinson disease · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P33908-F1 | alphafold | PREDICTED | 84.85 | — |
Amino-acid sequence (653 residues)
MPVGGLLPLF SSPAGGVLGG GLGGGGGRKG SGPAALRLTE KFVLLLVFSA FITLCFGAIF FLPDSSKLLS GVLFHSSPAL QPAADHKPGP GARAEDAAEG RARRREEGAP GDPEAALEDN LARIRENHER ALREAKETLQ KLPEEIQRDI LLEKKKVAQD QLRDKAPFRG LPPVDFVPPI GVESREPADA AIREKRAKIK EMMKHAWNNY KGYAWGLNEL KPISKGGHSS SLFGNIKGAT IVDALDTLFI MEMKHEFEEA KSWVEENLDF NVNAEISVFE VNIRFVGGLL SAYYLSGEEI FRKKAVELGV KLLPAFHTPS GIPWALLNMK SGIGRNWPWA SGGSSILAEF GTLHLEFMHL SHLSGNPIFA EKVMNIRTVL NKLEKPQGLY PNYLNPSSGQ WGQHHVSVGG LGDSFYEYLL KAWLMSDKTD LEAKKMYFDA VQAIETHLIR KSSSGLTYIA EWKGGLLEHK MGHLTCFAGG MFALGADAAP EGMAQHYLEL GAEIARTCHE SYNRTFMKLG PEAFRFDGGV EAIATRQNEK YYILRPEVME TYMYMWRLTH DPKYRKWAWE AVEALENHCR VNGGYSGLRD VYLLHESYDD VQQSFFLAET LKYLYLIFSD DDLLPLEHWI FNSEAHLLPI LPKDKKEVEI REE
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