About ER lumen protein-retaining receptor 2
ER lumen protein-retaining receptor 2 (KDELR2) is a protein
from Homo sapiens identified by UniProt accession
P33947, 212 residues long.
MolForge cross-references it against 0 known binders and
99 disease associations.
Target properties
| Protein name | ER lumen protein-retaining receptor 2 |
|---|
| UniProt accession | P33947 |
|---|
| Gene | KDELR2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 212 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (99)
Diseases linked to this target (Open Targets).
- osteogenesis imperfecta, type 21 · score 0.73
- scoliosis · score 0.46
- Increased susceptibility to fractures · score 0.46
- Joint hypermobility · score 0.46
- monocyte count · score 0.42
- Red cell distribution width · score 0.40
- mean platelet volume · score 0.39
- lymphocyte count · score 0.39
- neutrophil count · score 0.39
- osteogenesis imperfecta · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P33947-F1 | alphafold | PREDICTED | 92.99 | — |
Amino-acid sequence (212 residues)
MNIFRLTGDL SHLAAIVILL LKIWKTRSCA GISGKSQLLF ALVFTTRYLD LFTSFISLYN TSMKVIYLAC SYATVYLIYL KFKATYDGNH DTFRVEFLVV PVGGLSFLVN HDFSPLEILW TFSIYLESVA ILPQLFMISK TGEAETITTH YLFFLGLYRA LYLVNWIWRF YFEGFFDLIA VVAGVVQTIL YCDFFYLYIT KVLKGKKLSL PA
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