N-acetylgalactosamine-6-sulfatase (GALNS)

About N-acetylgalactosamine-6-sulfatase

N-acetylgalactosamine-6-sulfatase (GALNS) is a protein from Homo sapiens identified by UniProt accession P34059, 522 residues long. MolForge cross-references it against 0 known binders and 150 disease associations.

Target properties

Protein name	N-acetylgalactosamine-6-sulfatase
UniProt accession	P34059
Gene	GALNS
Organism	Homo sapiens
Length	522 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (150)

Diseases linked to this target (Open Targets).

mucopolysaccharidosis type 4A · score 0.88
mucopolysaccharidosis type 4 · score 0.66
genetic disorder · score 0.51
Skeletal dysplasia · score 0.41
classic galactosemia · score 0.34
hemophilia A · score 0.34
Abnormality of the skeletal system · score 0.27
Abnormality of metabolism/homeostasis · score 0.27
sitting height measurement · score 0.21
hair colour measurement · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P34059-F1	alphafold	PREDICTED	95.77	—

Amino-acid sequence (522 residues)

MAAVVAATRW WQLLLVLSAA GMGASGAPQP PNILLLLMDD MGWGDLGVYG EPSRETPNLD RMAAEGLLFP NFYSANPLCS PSRAALLTGR LPIRNGFYTT NAHARNAYTP QEIVGGIPDS EQLLPELLKK AGYVSKIVGK WHLGHRPQFH PLKHGFDEWF GSPNCHFGPY DNKARPNIPV YRDWEMVGRY YEEFPINLKT GEANLTQIYL QEALDFIKRQ ARHHPFFLYW AVDATHAPVY ASKPFLGTSQ RGRYGDAVRE IDDSIGKILE LLQDLHVADN TFVFFTSDNG AALISAPEQG GSNGPFLCGK QTTFEGGMRE PALAWWPGHV TAGQVSHQLG SIMDLFTTSL ALAGLTPPSD RAIDGLNLLP TLLQGRLMDR PIFYYRGDTL MAATLGQHKA HFWTWTNSWE NFRQGIDFCP GQNVSGVTTH NLEDHTKLPL IFHLGRDPGE RFPLSFASAE YQEALSRITS VVQQHQEALV PAQPQLNVCN WAVMNWAPPG CEKLGKCLTP PESIPKKCLW SH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards