About Ribonuclease 4
Ribonuclease 4 (RNASE4) is a protein
from Homo sapiens identified by UniProt accession
P34096, 147 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Target properties
| Protein name | Ribonuclease 4 |
|---|
| UniProt accession | P34096 |
|---|
| Gene | RNASE4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 147 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (26)
Diseases linked to this target (Open Targets).
- amyotrophic lateral sclerosis · score 0.51
- neurodegenerative disease · score 0.42
- blood protein measurement · score 0.38
- angiogenin measurement · score 0.35
- frontotemporal dementia · score 0.26
- genetic disorder · score 0.18
- familial amyotrophic lateral sclerosis · score 0.12
- frontotemporal dementia with motor neuron disease · score 0.12
- neoplasm · score 0.07
- protein measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P34096-F1 | alphafold | PREDICTED | 92.19 | — |
Amino-acid sequence (147 residues)
MALQRTHSLL LLLLLTLLGL GLVQPSYGQD GMYQRFLRQH VHPEETGGSD RYCNLMMQRR KMTLYHCKRF NTFIHEDIWN IRSICSTTNI QCKNGKMNCH EGVVKVTDCR DTGSSRAPNC RYRAIASTRR VVIACEGNPQ VPVHFDG
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