About Bone morphogenetic protein 8B
Bone morphogenetic protein 8B (BMP8B) is a protein
from Homo sapiens identified by UniProt accession
P34820, 402 residues long.
MolForge cross-references it against 0 known binders and
142 disease associations.
Target properties
| Protein name | Bone morphogenetic protein 8B |
|---|
| UniProt accession | P34820 |
|---|
| Gene | BMP8B |
|---|
| Organism | Homo sapiens |
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| Length | 402 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (142)
Diseases linked to this target (Open Targets).
- diabetes mellitus · score 0.29
- hemorrhoid · score 0.19
- heel bone mineral density · score 0.19
- anus disease · score 0.17
- rectal disease · score 0.17
- blood protein measurement · score 0.17
- peptidyl-prolyl cis-trans isomerase E measurement · score 0.14
- FEV/FVC ratio · score 0.10
- Snoring · score 0.10
- azoospermia · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P34820-F1 | alphafold | PREDICTED | 76.25 | — |
Amino-acid sequence (402 residues)
MTALPGPLWL LGLALCALGG GGPGLRPPPG CPQRRLGARE RRDVQREILA VLGLPGRPRP RAPPAASRLP ASAPLFMLDL YHAMAGDDDE DGAPAERRLG RADLVMSFVN MVERDRALGH QEPHWKEFRF DLTQIPAGEA VTAAEFRIYK VPSIHLLNRT LHVSMFQVVQ EQSNRESDLF FLDLQTLRAG DEGWLVLDVT AASDCWLLKR HKDLGLRLYV ETEDGHSVDP GLAGLLGQRA PRSQQPFVVT FFRASPSPIR TPRAVRPLRR RQPKKSNELP QANRLPGIFD DVHGSHGRQV CRRHELYVSF QDLGWLDWVI APQGYSAYYC EGECSFPLDS CMNATNHAIL QSLVHLMMPD AVPKACCAPT KLSATSVLYY DSSNNVILRK HRNMVVKACG CH
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