About Serine hydroxymethyltransferase, cytosolic
Serine hydroxymethyltransferase, cytosolic (SHMT1) is a protein
from Homo sapiens identified by UniProt accession
P34896, 483 residues long.
MolForge cross-references it against 0 known binders and
174 disease associations.
Target properties
| Protein name | Serine hydroxymethyltransferase, cytosolic |
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| UniProt accession | P34896 |
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| Gene | SHMT1 |
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| Organism | Homo sapiens |
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| Length | 483 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (174)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- multiple sclerosis · score 0.36
- Parkinson disease · score 0.35
- lysosomal storage disease · score 0.35
- Alzheimer disease · score 0.35
- blood protein measurement · score 0.34
- BMI-adjusted waist-hip ratio · score 0.32
- BMI-adjusted waist circumference · score 0.29
- IGF-1 measurement · score 0.24
- waist-hip ratio · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P34896-F1 | alphafold | PREDICTED | 96.60 | — |
Amino-acid sequence (483 residues)
MTMPVNGAHK DADLWSSHDK MLAQPLKDSD VEVYNIIKKE SNRQRVGLEL IASENFASRA VLEALGSCLN NKYSEGYPGQ RYYGGTEFID ELETLCQKRA LQAYKLDPQC WGVNVQPYSG SPANFAVYTA LVEPHGRIMG LDLPDGGHLT HGFMTDKKKI SATSIFFESM PYKVNPDTGY INYDQLEENA RLFHPKLIIA GTSCYSRNLE YARLRKIADE NGAYLMADMA HISGLVAAGV VPSPFEHCHV VTTTTHKTLR GCRAGMIFYR KGVKSVDPKT GKEILYNLES LINSAVFPGL QGGPHNHAIA GVAVALKQAM TLEFKVYQHQ VVANCRALSE ALTELGYKIV TGGSDNHLIL VDLRSKGTDG GRAEKVLEAC SIACNKNTCP GDRSALRPSG LRLGTPALTS RGLLEKDFQK VAHFIHRGIE LTLQIQSDTG VRATLKEFKE RLAGDKYQAA VQALREEVES FASLFPLPGL PDF
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