About Gamma-aminobutyric acid receptor subunit alpha-3
Gamma-aminobutyric acid receptor subunit alpha-3 (GABRA3) is a protein
from Homo sapiens identified by UniProt accession
P34903, 492 residues long.
MolForge cross-references it against 0 known binders and
356 disease associations.
Target properties
| Protein name | Gamma-aminobutyric acid receptor subunit alpha-3 |
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| UniProt accession | P34903 |
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| Gene | GABRA3 |
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| Organism | Homo sapiens |
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| Length | 492 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (356)
Diseases linked to this target (Open Targets).
- unipolar depression · score 0.61
- insomnia · score 0.61
- epilepsy · score 0.61
- osteoarthritis · score 0.60
- Agitation · score 0.60
- panic disorder · score 0.60
- pain · score 0.60
- anxiety disorder · score 0.60
- anxiety · score 0.60
- migraine disorder · score 0.60
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P34903-F1 | alphafold | PREDICTED | 76.35 | — |
Amino-acid sequence (492 residues)
MIITQTSHCY MTSLGILFLI NILPGTTGQG ESRRQEPGDF VKQDIGGLSP KHAPDIPDDS TDNITIFTRI LDRLLDGYDN RLRPGLGDAV TEVKTDIYVT SFGPVSDTDM EYTIDVFFRQ TWHDERLKFD GPMKILPLNN LLASKIWTPD TFFHNGKKSV AHNMTTPNKL LRLVDNGTLL YTMRLTIHAE CPMHLEDFPM DVHACPLKFG SYAYTTAEVV YSWTLGKNKS VEVAQDGSRL NQYDLLGHVV GTEIIRSSTG EYVVMTTHFH LKRKIGYFVI QTYLPCIMTV ILSQVSFWLN RESVPARTVF GVTTVLTMTT LSISARNSLP KVAYATAMDW FIAVCYAFVF SALIEFATVN YFTKRSWAWE GKKVPEALEM KKKTPAAPAK KTSTTFNIVG TTYPINLAKD TEFSTISKGA APSASSTPTI IASPKATYVQ DSPTETKTYN SVSKVDKISR IIFPVLFAIF NLVYWATYVN RESAIKGMIR KQ
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