About Tyrosine-protein kinase RYK
Tyrosine-protein kinase RYK (RYK) is a protein
from Homo sapiens identified by UniProt accession
P34925, 607 residues long.
MolForge cross-references it against 0 known binders and
209 disease associations.
Target properties
| Protein name | Tyrosine-protein kinase RYK |
|---|
| UniProt accession | P34925 |
|---|
| Gene | RYK |
|---|
| Organism | Homo sapiens |
|---|
| Length | 607 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (209)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.44
- diastolic blood pressure · score 0.39
- body height · score 0.38
- hypertension · score 0.36
- blood pressure · score 0.29
- ferritin measurement · score 0.28
- cardiovascular disease · score 0.27
- pulse pressure measurement · score 0.27
- facial morphology measurement · score 0.24
- testosterone measurement · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P34925-F1 | alphafold | PREDICTED | 79.65 | — |
Amino-acid sequence (607 residues)
MRGAARLGRP GRSCLPGARG LRAPPPPPLL LLLALLPLLP APGAAAAPAP RPPELQSASA GPSVSLYLSE DEVRRLIGLD AELYYVRNDL ISHYALSFSL LVPSETNFLH FTWHAKSKVE YKLGFQVDNV LAMDMPQVNI SVQGEVPRTL SVFRVELSCT GKVDSEVMIL MQLNLTVNSS KNFTVLNFKR RKMCYKKLEE VKTSALDKNT SRTIYDPVHA APTTSTRVFY ISVGVCCAVI FLVAIILAVL HLHSMKRIEL DDSISASSSS QGLSQPSTQT TQYLRADTPN NATPITSYPT LRIEKNDLRS VTLLEAKGKV KDIAISRERI TLKDVLQEGT FGRIFHGILI DEKDPNKEKQ AFVKTVKDQA SEIQVTMMLT ESCKLRGLHH RNLLPITHVC IEEGEKPMVI LPYMNWGNLK LFLRQCKLVE ANNPQAISQQ DLVHMAIQIA CGMSYLARRE VIHKDLAARN CVIDDTLQVK ITDNALSRDL FPMDYHCLGD NENRPVRWMA LESLVNNEFS SASDVWAFGV TLWELMTLGQ TPYVDIDPFE MAAYLKDGYR IAQPINCPDE LFAVMACCWA LDPEERPKFQ QLVQCLTEFH AALGAYV
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