About Heat shock 70 kDa protein 1-like
Heat shock 70 kDa protein 1-like (HSPA1L) is a protein
from Homo sapiens identified by UniProt accession
P34931, 641 residues long.
MolForge cross-references it against 0 known binders and
100 disease associations.
Target properties
| Protein name | Heat shock 70 kDa protein 1-like |
|---|
| UniProt accession | P34931 |
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| Gene | HSPA1L |
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| Organism | Homo sapiens |
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| Length | 641 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (100)
Diseases linked to this target (Open Targets).
- inflammatory bowel disease 1 · score 0.49
- chronic obstructive pulmonary disease · score 0.42
- inflammatory bowel disease · score 0.20
- neutrophil collagenase measurement · score 0.20
- complement C4 measurement · score 0.18
- breast adenocarcinoma · score 0.18
- low grade glioma · score 0.17
- gp41 C34 peptide, HIV measurement · score 0.14
- blood protein measurement · score 0.10
- head and neck squamous cell carcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P34931-F1 | alphafold | PREDICTED | 88.82 | — |
Amino-acid sequence (641 residues)
MATAKGIAIG IDLGTTYSCV GVFQHGKVEI IANDQGNRTT PSYVAFTDTE RLIGDAAKNQ VAMNPQNTVF DAKRLIGRKF NDPVVQADMK LWPFQVINEG GKPKVLVSYK GENKAFYPEE ISSMVLTKLK ETAEAFLGHP VTNAVITVPA YFNDSQRQAT KDAGVIAGLN VLRIINEPTA AAIAYGLDKG GQGERHVLIF DLGGGTFDVS ILTIDDGIFE VKATAGDTHL GGEDFDNRLV SHFVEEFKRK HKKDISQNKR AVRRLRTACE RAKRTLSSST QANLEIDSLY EGIDFYTSIT RARFEELCAD LFRGTLEPVE KALRDAKMDK AKIHDIVLVG GSTRIPKVQR LLQDYFNGRD LNKSINPDEA VAYGAAVQAA ILMGDKSEKV QDLLLLDVAP LSLGLETAGG VMTALIKRNS TIPTKQTQIF TTYSDNQPGV LIQVYEGERA MTKDNNLLGR FDLTGIPPAP RGVPQIEVTF DIDANGILNV TATDKSTGKV NKITITNDKG RLSKEEIERM VLDAEKYKAE DEVQREKIAA KNALESYAFN MKSVVSDEGL KGKISESDKN KILDKCNELL SWLEVNQLAE KDEFDHKRKE LEQMCNPIIT KLYQGGCTGP ACGTGYVPGR PATGPTIEEV D
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