About G protein-coupled receptor kinase 5
G protein-coupled receptor kinase 5 (GRK5) is a protein
from Homo sapiens identified by UniProt accession
P34947, 590 residues long.
MolForge cross-references it against 0 known binders and
179 disease associations.
Target properties
| Protein name | G protein-coupled receptor kinase 5 |
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| UniProt accession | P34947 |
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| Gene | GRK5 |
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| Organism | Homo sapiens |
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| Length | 590 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (179)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.50
- platelet count · score 0.48
- body height · score 0.48
- lymphocyte count · score 0.47
- venous thromboembolism · score 0.45
- platelet component distribution width · score 0.45
- appendicular lean mass · score 0.41
- CCL17 measurement · score 0.41
- blood protein measurement · score 0.41
- lymphocyte percentage of leukocytes · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P34947-F1 | alphafold | PREDICTED | 90.38 | — |
Amino-acid sequence (590 residues)
MELENIVANT VLLKAREGGG GKRKGKSKKW KEILKFPHIS QCEDLRRTID RDYCSLCDKQ PIGRLLFRQF CETRPGLECY IQFLDSVAEY EVTPDEKLGE KGKEIMTKYL TPKSPVFIAQ VGQDLVSQTE EKLLQKPCKE LFSACAQSVH EYLRGEPFHE YLDSMFFDRF LQWKWLERQP VTKNTFRQYR VLGKGGFGEV CACQVRATGK MYACKRLEKK RIKKRKGESM ALNEKQILEK VNSQFVVNLA YAYETKDALC LVLTIMNGGD LKFHIYNMGN PGFEEERALF YAAEILCGLE DLHRENTVYR DLKPENILLD DYGHIRISDL GLAVKIPEGD LIRGRVGTVG YMAPEVLNNQ RYGLSPDYWG LGCLIYEMIE GQSPFRGRKE KVKREEVDRR VLETEEVYSH KFSEEAKSIC KMLLTKDAKQ RLGCQEEGAA EVKRHPFFRN MNFKRLEAGM LDPPFVPDPR AVYCKDVLDI EQFSTVKGVN LDHTDDDFYS KFSTGSVSIP WQNEMIETEC FKELNVFGPN GTLPPDLNRN HPPEPPKKGL LQRLFKRQHQ NNSKSSPSSK TSFNHHINSN HVSSNSTGSS
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