About Mannose-6-phosphate isomerase
Mannose-6-phosphate isomerase (MPI) is a protein
from Homo sapiens identified by UniProt accession
P34949, 423 residues long.
MolForge cross-references it against 0 known binders and
75 disease associations.
Target properties
| Protein name | Mannose-6-phosphate isomerase |
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| UniProt accession | P34949 |
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| Gene | MPI |
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| Organism | Homo sapiens |
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| Length | 423 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (75)
Diseases linked to this target (Open Targets).
- MPI-congenital disorder of glycosylation · score 0.84
- congenital disorder of glycosylation · score 0.58
- neurodegenerative disease · score 0.53
- SRD5A3-congenital disorder of glycosylation · score 0.46
- congenital disorder of glycosylation type I · score 0.37
- Red cell distribution width · score 0.20
- genetic disorder · score 0.18
- diastolic blood pressure · score 0.14
- alcohol consumption measurement · score 0.13
- low density lipoprotein cholesterol measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P34949-F1 | alphafold | PREDICTED | 96.44 | — |
Amino-acid sequence (423 residues)
MAAPRVFPLS CAVQQYAWGK MGSNSEVARL LASSDPLAQI AEDKPYAELW MGTHPRGDAK ILDNRISQKT LSQWIAENQD SLGSKVKDTF NGNLPFLFKV LSVETPLSIQ AHPNKELAEK LHLQAPQHYP DANHKPEMAI ALTPFQGLCG FRPVEEIVTF LKKVPEFQFL IGDEAATHLK QTMSHDSQAV ASSLQSCFSH LMKSEKKVVV EQLNLLVKRI SQQAAAGNNM EDIFGELLLQ LHQQYPGDIG CFAIYFLNLL TLKPGEAMFL EANVPHAYLK GDCVECMACS DNTVRAGLTP KFIDVPTLCE MLSYTPSSSK DRLFLPTRSQ EDPYLSIYDP PVPDFTIMKT EVPGSVTEYK VLALDSASIL LMVQGTVIAS TPTTQTPIPL QRGGVLFIGA NESVSLKLTE PKDLLIFRAC CLL
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