Thyrotropin-releasing hormone receptor (TRHR)

About Thyrotropin-releasing hormone receptor

Thyrotropin-releasing hormone receptor (TRHR) is a protein from Homo sapiens identified by UniProt accession P34981, 398 residues long. MolForge cross-references it against 0 known binders and 105 disease associations.

Target properties

Protein name	Thyrotropin-releasing hormone receptor
UniProt accession	P34981
Gene	TRHR
Organism	Homo sapiens
Length	398 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (105)

Diseases linked to this target (Open Targets).

hypothyroidism, congenital, nongoitrous, 7 · score 0.61
pulse pressure measurement · score 0.41
type 2 diabetes mellitus · score 0.38
cerebellar ataxia · score 0.38
creatinine measurement · score 0.38
systolic blood pressure · score 0.34
leukocyte count · score 0.31
lean body mass · score 0.29
vital capacity · score 0.29
acute respiratory distress syndrome · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P34981-F1	alphafold	PREDICTED	79.64	—

Amino-acid sequence (398 residues)

MENETVSELN QTQLQPRAVV ALEYQVVTIL LVLIICGLGI VGNIMVVLVV MRTKHMRTPT NCYLVSLAVA DLMVLVAAGL PNITDSIYGS WVYGYVGCLC ITYLQYLGIN ASSCSITAFT IERYIAICHP IKAQFLCTFS RAKKIIIFVW AFTSLYCMLW FFLLDLNIST YKDAIVISCG YKISRNYYSP IYLMDFGVFY VVPMILATVL YGFIARILFL NPIPSDPKEN SKTWKNDSTH QNTNLNVNTS NRCFNSTVSS RKQVTKMLAV VVILFALLWM PYRTLVVVNS FLSSPFQENW FLLFCRICIY LNSAINPVIY NLMSQKFRAA FRKLCNCKQK PTEKPANYSV ALNYSVIKES DHFSTELDDI TVTDTYLSAT KVSFDDTCLA SEVSFSQS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards