About Glypican-1
Glypican-1 (GPC1) is a protein
from Homo sapiens identified by UniProt accession
P35052, 558 residues long.
MolForge cross-references it against 0 known binders and
229 disease associations.
Target properties
| Protein name | Glypican-1 |
|---|
| UniProt accession | P35052 |
|---|
| Gene | GPC1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 558 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (229)
Diseases linked to this target (Open Targets).
- COVID-19 · score 0.54
- body mass index · score 0.31
- protein measurement · score 0.30
- neuroticism measurement · score 0.28
- balding measurement · score 0.27
- cutaneous melanoma · score 0.25
- Keloid · score 0.24
- lung adenocarcinoma · score 0.23
- lean body mass · score 0.21
- hair shape measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P35052-F1 | alphafold | PREDICTED | 82.50 | — |
Amino-acid sequence (558 residues)
MELRARGWWL LCAAAALVAC ARGDPASKSR SCGEVRQIYG AKGFSLSDVP QAEISGEHLR ICPQGYTCCT SEMEENLANR SHAELETALR DSSRVLQAML ATQLRSFDDH FQHLLNDSER TLQATFPGAF GELYTQNARA FRDLYSELRL YYRGANLHLE ETLAEFWARL LERLFKQLHP QLLLPDDYLD CLGKQAEALR PFGEAPRELR LRATRAFVAA RSFVQGLGVA SDVVRKVAQV PLGPECSRAV MKLVYCAHCL GVPGARPCPD YCRNVLKGCL ANQADLDAEW RNLLDSMVLI TDKFWGTSGV ESVIGSVHTW LAEAINALQD NRDTLTAKVI QGCGNPKVNP QGPGPEEKRR RGKLAPRERP PSGTLEKLVS EAKAQLRDVQ DFWISLPGTL CSEKMALSTA SDDRCWNGMA RGRYLPEVMG DGLANQINNP EVEVDITKPD MTIRQQIMQL KIMTNRLRSA YNGNDVDFQD ASDDGSGSGS GDGCLDDLCS RKVSRKSSSS RTPLTHALPG LSEQEGQKTS AASCPQPPTF LLPLLLFLAL TVARPRWR
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