About Profilin-2
Profilin-2 (PFN2) is a protein
from Homo sapiens identified by UniProt accession
P35080, 140 residues long.
MolForge cross-references it against 0 known binders and
89 disease associations.
Target properties
| Protein name | Profilin-2 |
|---|
| UniProt accession | P35080 |
|---|
| Gene | PFN2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 140 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (89)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- pulse pressure measurement · score 0.31
- sex hormone-binding globulin measurement · score 0.16
- smoking status measurement · score 0.15
- attention deficit hyperactivity disorder · score 0.12
- substance abuse · score 0.12
- antisocial behaviour measurement · score 0.12
- myocardial infarction · score 0.09
- electrocardiography · score 0.08
- head and neck squamous cell carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P35080-F1 | alphafold | PREDICTED | 95.49 | — |
Amino-acid sequence (140 residues)
MAGWQSYVDN LMCDGCCQEA AIVGYCDAKY VWAATAGGVF QSITPIEIDM IVGKDREGFF TNGLTLGAKK CSVIRDSLYV DGDCTMDIRT KSQGGEPTYN VAVGRAGRVL VFVMGKEGVH GGGLNKKAYS MAKYLRDSGF
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