Gap junction alpha-4 protein (GJA4)

About Gap junction alpha-4 protein

Gap junction alpha-4 protein (GJA4) is a protein from Homo sapiens identified by UniProt accession P35212, 333 residues long. MolForge cross-references it against 0 known binders and 147 disease associations.

Target properties

Protein name	Gap junction alpha-4 protein
UniProt accession	P35212
Gene	GJA4
Organism	Homo sapiens
Length	333 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (147)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
Hepatic hemangioma · score 0.33
skin hemangioma · score 0.33
platelet component distribution width · score 0.26
lung adenocarcinoma · score 0.14
intraocular pressure measurement · score 0.12
daytime rest measurement · score 0.11
hip bone size · score 0.10
neoplasm · score 0.10
gastric adenocarcinoma · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P35212-F1	alphafold	PREDICTED	74.32	—

Amino-acid sequence (333 residues)

MGDWGFLEKL LDQVQEHSTV VGKIWLTVLF IFRILILGLA GESVWGDEQS DFECNTAQPG CTNVCYDQAF PISHIRYWVL QFLFVSTPTL VYLGHVIYLS RREERLRQKE GELRALPAKD PQVERALAAV ERQMAKISVA EDGRLRIRGA LMGTYVASVL CKSVLEAGFL YGQWRLYGWT MEPVFVCQRA PCPYLVDCFV SRPTEKTIFI IFMLVVGLIS LVLNLLELVH LLCRCLSRGM RARQGQDAPP TQGTSSDPYT DQVFFYLPVG QGPSSPPCPT YNGLSSSEQN WANLTTEERL ASSRPPLFLD PPPQNGQKPP SRPSSSASKK QYV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards