About Carbonic anhydrase-related protein
Carbonic anhydrase-related protein (CA8) is a protein
from Homo sapiens identified by UniProt accession
P35219, 290 residues long.
MolForge cross-references it against 0 known binders and
296 disease associations.
Target properties
| Protein name | Carbonic anhydrase-related protein |
|---|
| UniProt accession | P35219 |
|---|
| Gene | CA8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 290 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (296)
Diseases linked to this target (Open Targets).
- Dysequilibrium syndrome · score 0.76
- Rare hereditary ataxia · score 0.71
- erythrocyte count · score 0.42
- hemoglobin measurement · score 0.40
- hematocrit · score 0.38
- blood protein measurement · score 0.34
- body height · score 0.32
- thyroxine measurement · score 0.29
- Varicose veins · score 0.28
- red blood cell density measurement · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P35219-F1 | alphafold | PREDICTED | 90.51 | — |
Amino-acid sequence (290 residues)
MADLSFIEDT VAFPEKEEDE EEEEEGVEWG YEEGVEWGLV FPDANGEYQS PINLNSREAR YDPSLLDVRL SPNYVVCRDC EVTNDGHTIQ VILKSKSVLS GGPLPQGHEF ELYEVRFHWG RENQRGSEHT VNFKAFPMEL HLIHWNSTLF GSIDEAVGKP HGIAIIALFV QIGKEHVGLK AVTEILQDIQ YKGKSKTIPC FNPNTLLPDP LLRDYWVYEG SLTIPPCSEG VTWILFRYPL TISQLQIEEF RRLRTHVKGA ELVEGCDGIL GDNFRPTQPL SDRVIRAAFQ
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