Polycomb complex protein BMI-1 (BMI1)

About Polycomb complex protein BMI-1

Polycomb complex protein BMI-1 (BMI1) is a protein from Homo sapiens identified by UniProt accession P35226, 326 residues long. MolForge cross-references it against 0 known binders and 189 disease associations.

Target properties

Protein name	Polycomb complex protein BMI-1
UniProt accession	P35226
Gene	BMI1
Organism	Homo sapiens
Length	326 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (189)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
breast adenocarcinoma · score 0.26
ovarian cancer · score 0.26
glioblastoma multiforme · score 0.26
endometrial cancer · score 0.25
esophageal cancer · score 0.20
head and neck squamous cell carcinoma · score 0.19
gastric adenocarcinoma · score 0.12
bladder neck obstruction · score 0.09
body height · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P35226-F1	alphafold	PREDICTED	76.73	—

Amino-acid sequence (326 residues)

MHRTTRIKIT ELNPHLMCVL CGGYFIDATT IIECLHSFCK TCIVRYLETS KYCPICDVQV HKTRPLLNIR SDKTLQDIVY KLVPGLFKNE MKRRRDFYAA HPSADAANGS NEDRGEVADE DKRIITDDEI ISLSIEFFDQ NRLDRKVNKD KEKSKEEVND KRYLRCPAAM TVMHLRKFLR SKMDIPNTFQ IDVMYEEEPL KDYYTLMDIA YIYTWRRNGP LPLKYRVRPT CKRMKISHQR DGLTNAGELE SDSGSDKANS PAGGIPSTSS CLPSPSTPVQ SPHPQFPHIS STMNGTSNSP SGNHQSSFAN RPRKSSVNGS SATSSG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards