Polycomb group RING finger protein 2 (PCGF2)

About Polycomb group RING finger protein 2

Polycomb group RING finger protein 2 (PCGF2) is a protein from Homo sapiens identified by UniProt accession P35227, 344 residues long. MolForge cross-references it against 0 known binders and 189 disease associations.

Target properties

Protein name	Polycomb group RING finger protein 2
UniProt accession	P35227
Gene	PCGF2
Organism	Homo sapiens
Length	344 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (189)

Diseases linked to this target (Open Targets).

turnpenny-fry syndrome · score 0.61
Intellectual disability · score 0.59
genetic disorder · score 0.45
Global developmental delay · score 0.44
Abnormality of the skeletal system · score 0.37
Abnormality of the cardiovascular system · score 0.37
Abnormality of the outer ear · score 0.26
Abnormal pinna morphology · score 0.26
breast adenocarcinoma · score 0.26
neurodegenerative disease · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P35227-F1	alphafold	PREDICTED	73.33	—

Amino-acid sequence (344 residues)

MHRTTRIKIT ELNPHLMCAL CGGYFIDATT IVECLHSFCK TCIVRYLETN KYCPMCDVQV HKTRPLLSIR SDKTLQDIVY KLVPGLFKDE MKRRRDFYAA YPLTEVPNGS NEDRGEVLEQ EKGALSDDEI VSLSIEFYEG ARDRDEKKGP LENGDGDKEK TGVRFLRCPA AMTVMHLAKF LRNKMDVPSK YKVEVLYEDE PLKEYYTLMD IAYIYPWRRN GPLPLKYRVQ PACKRLTLAT VPTPSEGTNT SGASECESVS DKAPSPATLP ATSSSLPSPA TPSHGSPSSH GPPATHPTSP TPPSTASGAT TAANGGSLNC LQTPSSTSRG RKMTVNGAPV PPLT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards