About Prohibitin 1
Prohibitin 1 (PHB1) is a protein
from Homo sapiens identified by UniProt accession
P35232, 272 residues long.
MolForge cross-references it against 0 known binders and
319 disease associations.
Target properties
| Protein name | Prohibitin 1 |
|---|
| UniProt accession | P35232 |
|---|
| Gene | PHB1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 272 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (319)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.32
- FEV/FVC ratio · score 0.28
- hematocrit · score 0.28
- coronary artery disease · score 0.25
- hemoglobin measurement · score 0.25
- adult onset asthma · score 0.22
- leukocyte count · score 0.21
- behavior or behavioral disorder measurement · score 0.21
- heart disease · score 0.21
- appendicular lean mass · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P35232-F1 | alphafold | PREDICTED | 89.27 | — |
Amino-acid sequence (272 residues)
MAAKVFESIG KFGLALAVAG GVVNSALYNV DAGHRAVIFD RFRGVQDIVV GEGTHFLIPW VQKPIIFDCR SRPRNVPVIT GSKDLQNVNI TLRILFRPVA SQLPRIFTSI GEDYDERVLP SITTEILKSV VARFDAGELI TQRELVSRQV SDDLTERAAT FGLILDDVSL THLTFGKEFT EAVEAKQVAQ QEAERARFVV EKAEQQKKAA IISAEGDSKA AELIANSLAT AGDGLIELRK LEAAEDIAYQ LSRSRNITYL PAGQSVLLQL PQ
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