Serpin B6 (SERPINB6)

About Serpin B6

Serpin B6 (SERPINB6) is a protein from Homo sapiens identified by UniProt accession P35237, 376 residues long. MolForge cross-references it against 0 known binders and 90 disease associations.

Target properties

Protein name	Serpin B6
UniProt accession	P35237
Gene	SERPINB6
Organism	Homo sapiens
Length	376 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (90)

Diseases linked to this target (Open Targets).

deafness · score 0.52
hearing loss, autosomal recessive · score 0.52
hearing loss · score 0.37
chronic lymphocytic leukemia · score 0.30
neurodegenerative disease · score 0.30
lysosomal storage disease · score 0.30
Parkinson disease · score 0.30
multiple sclerosis · score 0.30
Alzheimer disease · score 0.30
Rare genetic deafness · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P35237-F1	alphafold	PREDICTED	90.54	—

Amino-acid sequence (376 residues)

MDVLAEANGT FALNLLKTLG KDNSKNVFFS PMSMSCALAM VYMGAKGNTA AQMAQILSFN KSGGGGDIHQ GFQSLLTEVN KTGTQYLLRM ANRLFGEKSC DFLSSFRDSC QKFYQAEMEE LDFISAVEKS RKHINTWVAE KTEGKIAELL SPGSVDPLTR LVLVNAVYFR GNWDEQFDKE NTEERLFKVS KNEEKPVQMM FKQSTFKKTY IGEIFTQILV LPYVGKELNM IIMLPDETTD LRTVEKELTY EKFVEWTRLD MMDEEEVEVS LPRFKLEESY DMESVLRNLG MTDAFELGKA DFSGMSQTDL SLSKVVHKSF VEVNEEGTEA AAATAAIMMM RCARFVPRFC ADHPFLFFIQ HSKTNGILFC GRFSSP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards