Replication protein A 14 kDa subunit (RPA3)

About Replication protein A 14 kDa subunit

Replication protein A 14 kDa subunit (RPA3) is a protein from Homo sapiens identified by UniProt accession P35244, 121 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.

Target properties

Protein name	Replication protein A 14 kDa subunit
UniProt accession	P35244
Gene	RPA3
Organism	Homo sapiens
Length	121 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (64)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.36
breast adenocarcinoma · score 0.29
endometrial cancer · score 0.28
interstitial lung disease · score 0.22
neuroticism measurement · score 0.20
gastric adenocarcinoma · score 0.17
urinary bladder cancer · score 0.10
toxic epidermal necrolysis · score 0.06
Stevens-Johnson syndrome · score 0.06
bone density · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P35244-F1	alphafold	PREDICTED	93.19	—

Amino-acid sequence (121 residues)

MVDMMDLPRS RINAGMLAQF IDKPVCFVGR LEKIHPTGKM FILSDGEGKN GTIELMEPLD EEISGIVEVV GRVTAKATIL CTSYVQFKED SHPFDLGLYN EAVKIIHDFP QFYPLGIVQH D

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards