Pulmonary surfactant-associated protein D (SFTPD)

About Pulmonary surfactant-associated protein D

Pulmonary surfactant-associated protein D (SFTPD) is a protein from Homo sapiens identified by UniProt accession P35247, 375 residues long. MolForge cross-references it against 0 known binders and 375 disease associations.

Target properties

Protein name	Pulmonary surfactant-associated protein D
UniProt accession	P35247
Gene	SFTPD
Organism	Homo sapiens
Length	375 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (375)

Diseases linked to this target (Open Targets).

chronic obstructive pulmonary disease · score 0.46
COVID-19 · score 0.39
severe acute respiratory syndrome · score 0.38
blood protein measurement · score 0.36
FEV/FVC ratio · score 0.31
surfactant protein D measurement · score 0.25
rheumatoid arthritis · score 0.25
cutaneous melanoma · score 0.24
hemoglobin measurement · score 0.16
mean corpuscular hemoglobin concentration · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P35247-F1	alphafold	PREDICTED	65.51	—

Amino-acid sequence (375 residues)

MLLFLLSALV LLTQPLGYLE AEMKTYSHRT MPSACTLVMC SSVESGLPGR DGRDGREGPR GEKGDPGLPG AAGQAGMPGQ AGPVGPKGDN GSVGEPGPKG DTGPSGPPGP PGVPGPAGRE GPLGKQGNIG PQGKPGPKGE AGPKGEVGAP GMQGSAGARG LAGPKGERGV PGERGVPGNT GAAGSAGAMG PQGSPGARGP PGLKGDKGIP GDKGAKGESG LPDVASLRQQ VEALQGQVQH LQAAFSQYKK VELFPNGQSV GEKIFKTAGF VKPFTEAQLL CTQAGGQLAS PRSAAENAAL QQLVVAKNEA AFLSMTDSKT EGKFTYPTGE SLVYSNWAPG EPNDDGGSED CVEIFTNGKW NDRACGEKRL VVCEF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards