General transcription factor IIF subunit 1 (GTF2F1)

About General transcription factor IIF subunit 1

General transcription factor IIF subunit 1 (GTF2F1) is a protein from Homo sapiens identified by UniProt accession P35269, 517 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.

Target properties

Protein name	General transcription factor IIF subunit 1
UniProt accession	P35269
Gene	GTF2F1
Organism	Homo sapiens
Length	517 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (25)

Diseases linked to this target (Open Targets).

HIV infection · score 0.60
neurodegenerative disease · score 0.52
acrocephalosyndactyly · score 0.37
influenza · score 0.37
breast adenocarcinoma · score 0.28
lung adenocarcinoma · score 0.27
clear cell renal carcinoma · score 0.27
head and neck squamous cell carcinoma · score 0.25
low grade glioma · score 0.25
chronic lymphocytic leukemia · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P35269-F1	alphafold	PREDICTED	62.28	—

Amino-acid sequence (517 residues)

MAALGPSSQN VTEYVVRVPK NTTKKYNIMA FNAADKVNFA TWNQARLERD LSNKKIYQEE EMPESGAGSE FNRKLREEAR RKKYGIVLKE FRPEDQPWLL RVNGKSGRKF KGIKKGGVTE NTSYYIFTQC PDGAFEAFPV HNWYNFTPLA RHRTLTAEEA EEEWERRNKV LNHFSIMQQR RLKDQDQDED EEEKEKRGRR KASELRIHDL EDDLEMSSDA SDASGEEGGR VPKAKKKAPL AKGGRKKKKK KGSDDEAFED SDDGDFEGQE VDYMSDGSSS SQEEPESKAK APQQEEGPKG VDEQSDSSEE SEEEKPPEED KEEEEEKKAP TPQEKKRRKD SSEESDSSEE SDIDSEASSA LFMAKKKTPP KRERKPSGGS SRGNSRPGTP SAEGGSTSST LRAAASKLEQ GKRVSEMPAA KRLRLDTGPQ SLSGKSTPQP PSGKTTPNSG DVQVTEDAVR RYLTRKPMTT KDLLKKFQTK KTGLSSEQTV NVLAQILKRL NPERKMINDK MHFSLKE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards