About Nuclear receptor ROR-alpha
Nuclear receptor ROR-alpha (RORA) is a protein
from Homo sapiens identified by UniProt accession
P35398, 523 residues long.
MolForge cross-references it against 0 known binders and
669 disease associations.
Target properties
| Protein name | Nuclear receptor ROR-alpha |
|---|
| UniProt accession | P35398 |
|---|
| Gene | RORA |
|---|
| Organism | Homo sapiens |
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| Length | 523 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (669)
Diseases linked to this target (Open Targets).
- intellectual developmental disorder with or without epilepsy or cerebellar ataxia · score 0.74
- Intellectual disability · score 0.52
- body height · score 0.50
- body mass index · score 0.48
- protein measurement · score 0.47
- genetic disorder · score 0.47
- asthma · score 0.45
- eosinophil count · score 0.45
- blood urea nitrogen measurement · score 0.44
- BMI-adjusted waist circumference · score 0.44
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P35398-F1 | alphafold | PREDICTED | 75.28 | — |
Amino-acid sequence (523 residues)
MESAPAAPDP AASEPGSSGA DAAAGSRETP LNQESARKSE PPAPVRRQSY SSTSRGISVT KKTHTSQIEI IPCKICGDKS SGIHYGVITC EGCKGFFRRS QQSNATYSCP RQKNCLIDRT SRNRCQHCRL QKCLAVGMSR DAVKFGRMSK KQRDSLYAEV QKHRMQQQQR DHQQQPGEAE PLTPTYNISA NGLTELHDDL SNYIDGHTPE GSKADSAVSS FYLDIQPSPD QSGLDINGIK PEPICDYTPA SGFFPYCSFT NGETSPTVSM AELEHLAQNI SKSHLETCQY LREELQQITW QTFLQEEIEN YQNKQREVMW QLCAIKITEA IQYVVEFAKR IDGFMELCQN DQIVLLKAGS LEVVFIRMCR AFDSQNNTVY FDGKYASPDV FKSLGCEDFI SFVFEFGKSL CSMHLTEDEI ALFSAFVLMS ADRSWLQEKV KIEKLQQKIQ LALQHVLQKN HREDGILTKL ICKVSTLRAL CGRHTEKLMA FKAIYPDIVR LHFPPLYKEL FTSEFEPAMQ IDG
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