Mas-related G-protein coupled receptor MRG (MAS1L)

About Mas-related G-protein coupled receptor MRG

Mas-related G-protein coupled receptor MRG (MAS1L) is a protein from Homo sapiens identified by UniProt accession P35410, 378 residues long. MolForge cross-references it against 0 known binders and 150 disease associations.

Target properties

Protein name	Mas-related G-protein coupled receptor MRG
UniProt accession	P35410
Gene	MAS1L
Organism	Homo sapiens
Length	378 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (150)

Diseases linked to this target (Open Targets).

leukocyte count · score 0.21
body height · score 0.19
neutrophil count · score 0.15
total blood protein measurement · score 0.09
melanoma · score 0.07
oral squamous cell carcinoma · score 0.06
creatinine measurement · score 0.05
female reproductive system disease · score 0.05
schizophrenia · score 0.05
response to vaccine · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P35410-F1	alphafold	PREDICTED	66.90	—

Amino-acid sequence (378 residues)

MVWGKICWFS QRAGWTVFAE SQISLSCSLC LHSGDQEAQN PNLVSQLCGV FLQNETNETI HMQMSMAVGQ QALPLNIIAP KAVLVSLCGV LLNGTVFWLL CCGATNPYMV YILHLVAADV IYLCCSAVGF LQVTLLTYHG VVFFIPDFLA ILSPFSFEVC LCLLVAISTE RCVCVLFPIW YRCHRPKYTS NVVCTLIWGL PFCINIVKSL FLTYWKHVKA CVIFLKLSGL FHAILSLVMC VSSLTLLIRF LCCSQQQKAT RVYAVVQISA PMFLLWALPL SVAPLITDFK MFVTTSYLIS LFLIINSSAN PIIYFFVGSL RKKRLKESLR VILQRALADK PEVGRNKKAA GIDPMEQPHS TQHVENLLPR EHRVDVET

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards