About Homeobox protein Hox-D12
Homeobox protein Hox-D12 (HOXD12) is a protein
from Homo sapiens identified by UniProt accession
P35452, 270 residues long.
MolForge cross-references it against 0 known binders and
487 disease associations.
Target properties
| Protein name | Homeobox protein Hox-D12 |
|---|
| UniProt accession | P35452 |
|---|
| Gene | HOXD12 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 270 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (487)
Diseases linked to this target (Open Targets).
- lean body mass · score 0.36
- body height · score 0.33
- heel bone mineral density · score 0.33
- fat body mass · score 0.31
- digit length ratio · score 0.30
- bone quantitative ultrasound measurement · score 0.29
- urate measurement · score 0.28
- whole body water mass · score 0.25
- base metabolic rate measurement · score 0.25
- hemorrhoid · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P35452-F1 | alphafold | PREDICTED | 63.22 | — |
Amino-acid sequence (270 residues)
MCERSLYRAG YVGSLLNLQS PDSFYFSNLR PNGGQLAALP PISYPRGALP WAATPASCAP AQPAGATAFG GFSQPYLAGS GPLGLQPPTA KDGPEEQAKF YAPEAAAGPE ERGRTRPSFA PESSLAPAVA ALKAAKYDYA GVGRATPGST TLLQGAPCAP GFKDDTKGPL NLNMTVQAAG VASCLRPSLP DGLPWGAAPG RARKKRKPYT KQQIAELENE FLVNEFINRQ KRKELSNRLN LSDQQVKIWF QNRRMKKKRV VLREQALALY
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