Homeobox protein Hox-D13 (HOXD13)

About Homeobox protein Hox-D13

Homeobox protein Hox-D13 (HOXD13) is a protein from Homo sapiens identified by UniProt accession P35453, 343 residues long. MolForge cross-references it against 0 known binders and 882 disease associations.

Target properties

Protein name	Homeobox protein Hox-D13
UniProt accession	P35453
Gene	HOXD13
Organism	Homo sapiens
Length	343 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (882)

Diseases linked to this target (Open Targets).

synpolydactyly type 1 · score 0.79
brachydactyly-syndactyly syndrome · score 0.75
syndactyly type 5 · score 0.75
Syndactyly type 2 · score 0.72
brachydactyly type E1 · score 0.69
non-syndromic brachydactyly · score 0.62
brachydactyly type E · score 0.56
VACTERL/vater association · score 0.51
polydactyly · score 0.45
zygodactyly type 3 · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P35453-F1	alphafold	PREDICTED	55.35	—

Amino-acid sequence (343 residues)

MSRAGSWDMD GLRADGGGAG GAPASSSSSS VAAAAASGQC RGFLSAPVFA GTHSGRAAAA AAAAAAAAAA ASGFAYPGTS ERTGSSSSSS SSAVVAARPE APPAKECPAP TPAAAAAAPP SAPALGYGYH FGNGYYSCRM SHGVGLQQNA LKSSPHASLG GFPVEKYMDV SGLASSSVPA NEVPARAKEV SFYQGYTSPY QHVPGYIDMV STFGSGEPRH EAYISMEGYQ SWTLANGWNS QVYCTKDQPQ GSHFWKSSFP GDVALNQPDM CVYRRGRKKR VPYTKLQLKE LENEYAINKF INKDKRRRIS AATNLSERQV TIWFQNRRVK DKKIVSKLKD TVS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards