About UDP-glucuronosyltransferase 1A5
UDP-glucuronosyltransferase 1A5 (UGT1A5) is a protein
from Homo sapiens identified by UniProt accession
P35504, 534 residues long.
MolForge cross-references it against 0 known binders and
48 disease associations.
Target properties
| Protein name | UDP-glucuronosyltransferase 1A5 |
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| UniProt accession | P35504 |
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| Gene | UGT1A5 |
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| Organism | Homo sapiens |
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| Length | 534 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (48)
Diseases linked to this target (Open Targets).
- bilirubin measurement · score 0.61
- Gilbert syndrome · score 0.61
- Crigler-Najjar syndrome type 1 · score 0.56
- Crigler-Najjar syndrome type 2 · score 0.55
- Crigler-Najjar syndrome · score 0.53
- transient familial neonatal hyperbilirubinemia · score 0.52
- porphyrin metabolism disease · score 0.51
- bilirubin metabolism disease · score 0.51
- Hyperbilirubinemia · score 0.51
- genetic disorder · score 0.49
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P35504-F1 | alphafold | PREDICTED | 91.46 | — |
Amino-acid sequence (534 residues)
MATGLQVPLP QLATGLLLLL SVQPWAESGK VLVVPTDGSH WLSMREALRD LHARGHQVVV LTLEVNMYIK EENFFTLTTY AISWTQDEFD RLLLGHTQSF FETEHLLMKF SRRMAIMNNM SLIIHRSCVE LLHNEALIRH LHATSFDVVL TDPFHLCAAV LAKYLSIPAV FFLRNIPCDL DFKGTQCPNP SSYIPRLLTT NSDHMTFLQR VKNMLYPLAL SYLCHAVSAP YASLASELFQ REVSVVDLVS HASVWLFRGD FVMDYPRPIM PNMVFIGGIN CANGKPLSQE FEAYINASGE HGIVVFSLGS MVSEIPEKKA MAIADALGKI PQTVLWRYTG TRPSNLANNT ILVKWLPQND LLGHPMTRAF ITHAGSHGVY ESICNGVPMV MMPLFGDQMD NAKRMETKGA GVTLNVLEMT SEDLENALKA VINDKSYKEN IMRLSSLHKD RPVEPLDLAV FWVEFVMRHK GAPHLRPAAH DLTWYQYHSL DVIGFLLAVV LTVAFITFKC CAYGYRKCLG KKGRVKKAHK SKTH
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