About Cystathionine beta-synthase
Cystathionine beta-synthase (CBS) is a protein
from Homo sapiens identified by UniProt accession
P35520, 551 residues long.
MolForge cross-references it against 0 known binders and
285 disease associations.
Target properties
| Protein name | Cystathionine beta-synthase |
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| UniProt accession | P35520 |
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| Gene | CBS |
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| Organism | Homo sapiens |
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| Length | 551 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (285)
Diseases linked to this target (Open Targets).
- classic homocystinuria · score 0.88
- Classical homocystinuria · score 0.86
- homocystinuria · score 0.56
- familial thoracic aortic aneurysm and aortic dissection · score 0.54
- Rare disease with thoracic aortic aneurysm and aortic dissection · score 0.54
- homocysteine measurement · score 0.46
- Marfan syndrome · score 0.42
- neutrophil count · score 0.41
- connective tissue disease · score 0.40
- Abnormality of the cardiovascular system · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P35520-F1 | alphafold | PREDICTED | 90.05 | — |
Amino-acid sequence (551 residues)
MPSETPQAEV GPTGCPHRSG PHSAKGSLEK GSPEDKEAKE PLWIRPDAPS RCTWQLGRPA SESPHHHTAP AKSPKILPDI LKKIGDTPMV RINKIGKKFG LKCELLAKCE FFNAGGSVKD RISLRMIEDA ERDGTLKPGD TIIEPTSGNT GIGLALAAAV RGYRCIIVMP EKMSSEKVDV LRALGAEIVR TPTNARFDSP ESHVGVAWRL KNEIPNSHIL DQYRNASNPL AHYDTTADEI LQQCDGKLDM LVASVGTGGT ITGIARKLKE KCPGCRIIGV DPEGSILAEP EELNQTEQTT YEVEGIGYDF IPTVLDRTVV DKWFKSNDEE AFTFARMLIA QEGLLCGGSA GSTVAVAVKA AQELQEGQRC VVILPDSVRN YMTKFLSDRW MLQKGFLKEE DLTEKKPWWW HLRVQELGLS APLTVLPTIT CGHTIEILRE KGFDQAPVVD EAGVILGMVT LGNMLSSLLA GKVQPSDQVG KVIYKQFKQI RLTDTLGRLS HILEMDHFAL VVHEQIQYHS TGKSSQRQMV FGVVTAIDLL NFVAAQERDQ K
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