About Keratin, type I cytoskeletal 9
Keratin, type I cytoskeletal 9 (KRT9) is a protein
from Homo sapiens identified by UniProt accession
P35527, 623 residues long.
MolForge cross-references it against 0 known binders and
184 disease associations.
Target properties
| Protein name | Keratin, type I cytoskeletal 9 |
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| UniProt accession | P35527 |
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| Gene | KRT9 |
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| Organism | Homo sapiens |
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| Length | 623 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (184)
Diseases linked to this target (Open Targets).
- epidermolytic palmoplantar keratoderma, 1 · score 0.73
- palmoplantar keratoderma, epidermolytic · score 0.64
- Localized epidermolytic hyperkeratosis · score 0.51
- Palmoplantar keratoderma · score 0.44
- genetic disorder · score 0.38
- head and neck squamous cell carcinoma · score 0.19
- ovarian cancer · score 0.18
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.18
- esophageal cancer · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P35527-F1 | alphafold | PREDICTED | 62.05 | — |
Amino-acid sequence (623 residues)
MSCRQFSSSY LSRSGGGGGG GLGSGGSIRS SYSRFSSSGG GGGGGRFSSS SGYGGGSSRV CGRGGGGSFG YSYGGGSGGG FSASSLGGGF GGGSRGFGGA SGGGYSSSGG FGGGFGGGSG GGFGGGYGSG FGGFGGFGGG AGGGDGGILT ANEKSTMQEL NSRLASYLDK VQALEEANND LENKIQDWYD KKGPAAIQKN YSPYYNTIDD LKDQIVDLTV GNNKTLLDID NTRMTLDDFR IKFEMEQNLR QGVDADINGL RQVLDNLTME KSDLEMQYET LQEELMALKK NHKEEMSQLT GQNSGDVNVE INVAPGKDLT KTLNDMRQEY EQLIAKNRKD IENQYETQIT QIEHEVSSSG QEVQSSAKEV TQLRHGVQEL EIELQSQLSK KAALEKSLED TKNRYCGQLQ MIQEQISNLE AQITDVRQEI ECQNQEYSLL LSIKMRLEKE IETYHNLLEG GQEDFESSGA GKIGLGGRGG SGGSYGRGSR GGSGGSYGGG GSGGGYGGGS GSRGGSGGSY GGGSGSGGGS GGGYGGGSGG GHSGGSGGGH SGGSGGNYGG GSGSGGGSGG GYGGGSGSRG GSGGSHGGGS GFGGESGGSY GGGEEASGSG GGYGGGSGKS SHS
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