About Homeobox protein MSX-2
Homeobox protein MSX-2 (MSX2) is a protein
from Homo sapiens identified by UniProt accession
P35548, 267 residues long.
MolForge cross-references it against 0 known binders and
443 disease associations.
Target properties
| Protein name | Homeobox protein MSX-2 |
|---|
| UniProt accession | P35548 |
|---|
| Gene | MSX2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 267 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (443)
Diseases linked to this target (Open Targets).
- Craniosynostosis, Boston type · score 0.73
- parietal foramina with cleidocranial dysplasia · score 0.72
- craniosynostosis 2 · score 0.68
- parietal foramina 1 · score 0.67
- parietal foramina · score 0.64
- hair color · score 0.46
- cortical surface area measurement · score 0.41
- craniosynostosis · score 0.38
- calcium measurement · score 0.35
- hair colour measurement · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P35548-F1 | alphafold | PREDICTED | 67.44 | — |
Amino-acid sequence (267 residues)
MASPSKGNDL FSPDEEGPAV VAGPGPGPGG AEGAAEERRV KVSSLPFSVE ALMSDKKPPK EASPLPAESA SAGATLRPLL LSGHGAREAH SPGPLVKPFE TASVKSENSE DGAAWMQEPG RYSPPPRHMS PTTCTLRKHK TNRKPRTPFT TSQLLALERK FRQKQYLSIA ERAEFSSSLN LTETQVKIWF QNRRAKAKRL QEAELEKLKM AAKPMLPSSF SLPFPISSPL QAASIYGASY PFHRPVLPIP PVGLYATPVG YGMYHLS
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