Hexokinase-4 (GCK)

About Hexokinase-4

Hexokinase-4 (GCK) is a protein from Homo sapiens identified by UniProt accession P35557, 465 residues long. MolForge cross-references it against 0 known binders and 339 disease associations.

Target properties

Protein name	Hexokinase-4
UniProt accession	P35557
Gene	GCK
Organism	Homo sapiens
Length	465 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (339)

Diseases linked to this target (Open Targets).

MODY · score 0.85
type 2 diabetes mellitus · score 0.85
maturity-onset diabetes of the young type 2 · score 0.84
permanent neonatal diabetes mellitus 1 · score 0.80
hyperinsulinism due to glucokinase deficiency · score 0.78
diabetes mellitus · score 0.75
maturity-onset diabetes of the young · score 0.70
HbA1c measurement · score 0.70
glucose measurement · score 0.69
monogenic diabetes · score 0.68

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P35557-F1	alphafold	PREDICTED	93.69	—

Amino-acid sequence (465 residues)

MLDDRARMEA AKKEKVEQIL AEFQLQEEDL KKVMRRMQKE MDRGLRLETH EEASVKMLPT YVRSTPEGSE VGDFLSLDLG GTNFRVMLVK VGEGEEGQWS VKTKHQMYSI PEDAMTGTAE MLFDYISECI SDFLDKHQMK HKKLPLGFTF SFPVRHEDID KGILLNWTKG FKASGAEGNN VVGLLRDAIK RRGDFEMDVV AMVNDTVATM ISCYYEDHQC EVGMIVGTGC NACYMEEMQN VELVEGDEGR MCVNTEWGAF GDSGELDEFL LEYDRLVDES SANPGQQLYE KLIGGKYMGE LVRLVLLRLV DENLLFHGEA SEQLRTRGAF ETRFVSQVES DTGDRKQIYN ILSTLGLRPS TTDCDIVRRA CESVSTRAAH MCSAGLAGVI NRMRESRSED VMRITVGVDG SVYKLHPSFK ERFHASVRRL TPSCEITFIE SEEGSGRGAA LVSAVACKKA CMLGQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards