About Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PCK1) is a protein
from Homo sapiens identified by UniProt accession
P35558, 622 residues long.
MolForge cross-references it against 0 known binders and
266 disease associations.
Target properties
| Protein name | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] |
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| UniProt accession | P35558 |
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| Gene | PCK1 |
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| Organism | Homo sapiens |
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| Length | 622 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (266)
Diseases linked to this target (Open Targets).
- phosphoenolpyruvate carboxykinase deficiency, cytosolic · score 0.64
- alkaline phosphatase measurement · score 0.48
- hemoglobin measurement · score 0.43
- phosphoenolpyruvate carboxykinase deficiency · score 0.42
- hematocrit · score 0.42
- genetic disorder · score 0.41
- waist-hip ratio · score 0.40
- erythrocyte count · score 0.39
- triglyceride measurement · score 0.37
- BMI-adjusted waist-hip ratio · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P35558-F1 | alphafold | PREDICTED | 96.44 | — |
Amino-acid sequence (622 residues)
MPPQLQNGLN LSAKVVQGSL DSLPQAVREF LENNAELCQP DHIHICDGSE EENGRLLGQM EEEGILRRLK KYDNCWLALT DPRDVARIES KTVIVTQEQR DTVPIPKTGL SQLGRWMSEE DFEKAFNARF PGCMKGRTMY VIPFSMGPLG SPLSKIGIEL TDSPYVVASM RIMTRMGTPV LEAVGDGEFV KCLHSVGCPL PLQKPLVNNW PCNPELTLIA HLPDRREIIS FGSGYGGNSL LGKKCFALRM ASRLAKEEGW LAEHMLILGI TNPEGEKKYL AAAFPSACGK TNLAMMNPSL PGWKVECVGD DIAWMKFDAQ GHLRAINPEN GFFGVAPGTS VKTNPNAIKT IQKNTIFTNV AETSDGGVYW EGIDEPLASG VTITSWKNKE WSSEDGEPCA HPNSRFCTPA SQCPIIDAAW ESPEGVPIEG IIFGGRRPAG VPLVYEALSW QHGVFVGAAM RSEATAAAEH KGKIIMHDPF AMRPFFGYNF GKYLAHWLSM AQHPAAKLPK IFHVNWFRKD KEGKFLWPGF GENSRVLEWM FNRIDGKAST KLTPIGYIPK EDALNLKGLG HINMMELFSI SKEFWEKEVE DIEKYLEDQV NADLPCEIER EILALKQRIS QM
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