Glucose-6-phosphatase catalytic subunit 1 (G6PC1)

About Glucose-6-phosphatase catalytic subunit 1

Glucose-6-phosphatase catalytic subunit 1 (G6PC1) is a protein from Homo sapiens identified by UniProt accession P35575, 357 residues long. MolForge cross-references it against 0 known binders and 293 disease associations.

Target properties

Protein name	Glucose-6-phosphatase catalytic subunit 1
UniProt accession	P35575
Gene	G6PC1
Organism	Homo sapiens
Length	357 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (293)

Diseases linked to this target (Open Targets).

glycogen storage disease due to glucose-6-phosphatase deficiency type IA · score 0.81
Glycogen storage disease due to glucose-6-phosphatase deficiency · score 0.74
Glycogen storage disease due to glucose-6-phosphatase deficiency type a · score 0.70
disorder of glycogen metabolism · score 0.58
glycogen storage disease I · score 0.48
genetic disorder · score 0.41
Hypoglycemia · score 0.35
Short stature · score 0.34
creatinine measurement · score 0.34
triglyceride measurement · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P35575-F1	alphafold	PREDICTED	92.21	—

Amino-acid sequence (357 residues)

MEEGMNVLHD FGIQSTHYLQ VNYQDSQDWF ILVSVIADLR NAFYVLFPIW FHLQEAVGIK LLWVAVIGDW LNLVFKWILF GQRPYWWVLD TDYYSNTSVP LIKQFPVTCE TGPGSPSGHA MGTAGVYYVM VTSTLSIFQG KIKPTYRFRC LNVILWLGFW AVQLNVCLSR IYLAAHFPHQ VVAGVLSGIA VAETFSHIHS IYNASLKKYF LITFFLFSFA IGFYLLLKGL GVDLLWTLEK AQRWCEQPEW VHIDTTPFAS LLKNLGTLFG LGLALNSSMY RESCKGKLSK WLPFRLSSIV ASLVLLHVFD SLKPPSQVEL VFYVLSFCKS AVVPLASVSV IPYCLAQVLG QPHKKSL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards