About Beta-adducin
Beta-adducin (ADD2) is a protein
from Homo sapiens identified by UniProt accession
P35612, 726 residues long.
MolForge cross-references it against 0 known binders and
284 disease associations.
Target properties
| Protein name | Beta-adducin |
|---|
| UniProt accession | P35612 |
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| Gene | ADD2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 726 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (284)
Diseases linked to this target (Open Targets).
- nasopharyngeal neoplasm · score 0.31
- PHF-tau measurement · score 0.30
- Blackfan-Diamond anemia · score 0.07
- dehydrated hereditary stomatocytosis · score 0.07
- severe congenital hypochromic anemia with ringed sideroblasts · score 0.07
- beta-thalassemia-X-linked thrombocytopenia syndrome · score 0.07
- hemoglobin D disease · score 0.07
- Hemolytic anemia due to red cell pyruvate kinase deficiency · score 0.07
- Congenital dyserythropoietic anemia type I · score 0.07
- primary familial polycythemia due to EPO receptor mutation · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P35612-F1 | alphafold | PREDICTED | 65.87 | — |
Amino-acid sequence (726 residues)
MSEETVPEAA SPPPPQGQPY FDRFSEDDPE YMRLRNRAAD LRQDFNLMEQ KKRVTMILQS PSFREELEGL IQEQMKKGNN SSNIWALRQI ADFMASTSHA VFPTSSMNVS MMTPINDLHT ADSLNLAKGE RLMRCKISSV YRLLDLYGWA QLSDTYVTLR VSKEQDHFLI SPKGVSCSEV TASSLIKVNI LGEVVEKGSS CFPVDTTGFC LHSAIYAARP DVRCIIHLHT PATAAVSAMK WGLLPVSHNA LLVGDMAYYD FNGEMEQEAD RINLQKCLGP TCKILVLRNH GVVALGDTVE EAFYKIFHLQ AACEIQVSAL SSAGGVENLI LLEQEKHRPH EVGSVQWAGS TFGPMQKSRL GEHEFEALMR MLDNLGYRTG YTYRHPFVQE KTKHKSEVEI PATVTAFVFE EDGAPVPALR QHAQKQQKEK TRWLNTPNTY LRVNVADEVQ RSMGSPRPKT TWMKADEVEK SSSGMPIRIE NPNQFVPLYT DPQEVLEMRN KIREQNRQDV KSAGPQSQLL ASVIAEKSRS PSTESQLMSK GDEDTKDDSE ETVPNPFSQL TDQELEEYKK EVERKKLELD GEKETAPEEP GSPAKSAPAS PVQSPAKEAE TKSPLVSPSK SLEEGTKKTE TSKAATTEPE TTQPEGVVVN GREEEQTAEE ILSKGLSQMT TSADTDVDTS KDKTESVTSG PMSPEGSPSK SPSKKKKKFR TPSFLKKSKK KEKVES
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