About G protein-coupled receptor kinase 3
G protein-coupled receptor kinase 3 (GRK3) is a protein
from Homo sapiens identified by UniProt accession
P35626, 688 residues long.
MolForge cross-references it against 0 known binders and
87 disease associations.
Target properties
| Protein name | G protein-coupled receptor kinase 3 |
|---|
| UniProt accession | P35626 |
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| Gene | GRK3 |
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| Organism | Homo sapiens |
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| Length | 688 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (87)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.29
- adolescent idiopathic scoliosis · score 0.28
- bone density · score 0.26
- body height · score 0.26
- visual perception measurement · score 0.20
- neoplasm · score 0.11
- hepatocellular carcinoma · score 0.08
- pachyonychia congenita · score 0.07
- gonorrhea · score 0.07
- breast cancer · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P35626-F1 | alphafold | PREDICTED | 89.39 | — |
Amino-acid sequence (688 residues)
MADLEAVLAD VSYLMAMEKS KATPAARASK RIVLPEPSIR SVMQKYLAER NEITFDKIFN QKIGFLLFKD FCLNEINEAV PQVKFYEEIK EYEKLDNEED RLCRSRQIYD AYIMKELLSC SHPFSKQAVE HVQSHLSKKQ VTSTLFQPYI EEICESLRGD IFQKFMESDK FTRFCQWKNV ELNIHLTMNE FSVHRIIGRG GFGEVYGCRK ADTGKMYAMK CLDKKRIKMK QGETLALNER IMLSLVSTGD CPFIVCMTYA FHTPDKLCFI LDLMNGGDLH YHLSQHGVFS EKEMRFYATE IILGLEHMHN RFVVYRDLKP ANILLDEHGH ARISDLGLAC DFSKKKPHAS VGTHGYMAPE VLQKGTAYDS SADWFSLGCM LFKLLRGHSP FRQHKTKDKH EIDRMTLTVN VELPDTFSPE LKSLLEGLLQ RDVSKRLGCH GGGSQEVKEH SFFKGVDWQH VYLQKYPPPL IPPRGEVNAA DAFDIGSFDE EDTKGIKLLD CDQELYKNFP LVISERWQQE VTETVYEAVN ADTDKIEARK RAKNKQLGHE EDYALGKDCI MHGYMLKLGN PFLTQWQRRY FYLFPNRLEW RGEGESRQNL LTMEQILSVE ETQIKDKKCI LFRIKGGKQF VLQCESDPEF VQWKKELNET FKEAQRLLRR APKFLNKPRS GTVELPKPSL CHRNSNGL
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