RNA-binding protein FUS (FUS)

About RNA-binding protein FUS

RNA-binding protein FUS (FUS) is a protein from Homo sapiens identified by UniProt accession P35637, 526 residues long. MolForge cross-references it against 0 known binders and 461 disease associations.

Target properties

Protein name	RNA-binding protein FUS
UniProt accession	P35637
Gene	FUS
Organism	Homo sapiens
Length	526 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (461)

Diseases linked to this target (Open Targets).

sporadic amyotrophic lateral sclerosis · score 0.81
amyotrophic lateral sclerosis · score 0.70
essential tremor · score 0.68
frontotemporal dementia with motor neuron disease · score 0.66
juvenile amyotrophic lateral sclerosis · score 0.52
genetic disorder · score 0.41
Amyotrophic lateral sclerosis · score 0.38
undifferentiated pleomorphic sarcoma · score 0.37
synovial sarcoma · score 0.37
liposarcoma · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P35637-F1	alphafold	PREDICTED	53.60	—

Amino-acid sequence (526 residues)

MASNDYTQQA TQSYGAYPTQ PGQGYSQQSS QPYGQQSYSG YSQSTDTSGY GQSSYSSYGQ SQNTGYGTQS TPQGYGSTGG YGSSQSSQSS YGQQSSYPGY GQQPAPSSTS GSYGSSSQSS SYGQPQSGSY SQQPSYGGQQ QSYGQQQSYN PPQGYGQQNQ YNSSSGGGGG GGGGGNYGQD QSSMSSGGGS GGGYGNQDQS GGGGSGGYGQ QDRGGRGRGG SGGGGGGGGG GYNRSSGGYE PRGRGGGRGG RGGMGGSDRG GFNKFGGPRD QGSRHDSEQD NSDNNTIFVQ GLGENVTIES VADYFKQIGI IKTNKKTGQP MINLYTDRET GKLKGEATVS FDDPPSAKAA IDWFDGKEFS GNPIKVSFAT RRADFNRGGG NGRGGRGRGG PMGRGGYGGG GSGGGGRGGF PSGGGGGGGQ QRAGDWKCPN PTCENMNFSW RNECNQCKAP KPDGPGGGPG GSHMGGNYGD DRRGGRGGYD RGGYRGRGGD RGGFRGGRGG GDRGGFGPGK MDSRGEHRQD RRERPY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards