DNA damage-inducible transcript 3 protein (DDIT3)

About DNA damage-inducible transcript 3 protein

DNA damage-inducible transcript 3 protein (DDIT3) is a protein from Homo sapiens identified by UniProt accession P35638, 169 residues long. MolForge cross-references it against 0 known binders and 687 disease associations.

Target properties

Protein name	DNA damage-inducible transcript 3 protein
UniProt accession	P35638
Gene	DDIT3
Organism	Homo sapiens
Length	169 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (687)

Diseases linked to this target (Open Targets).

well-differentiated liposarcoma · score 0.37
lipoma · score 0.37
extraskeletal myxoid chondrosarcoma · score 0.37
myxofibrosarcoma · score 0.37
pleomorphic liposarcoma · score 0.37
myxoma · score 0.37
dedifferentiated liposarcoma · score 0.37
liposarcoma · score 0.37
mixed liposarcoma · score 0.37
neurodegenerative disease · score 0.35

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P35638-F1	alphafold	PREDICTED	70.25	—

Amino-acid sequence (169 residues)

MAAESLPFSF GTLSSWELEA WYEDLQEVLS SDENGGTYVS PPGNEEEESK IFTTLDPASL AWLTEEEPEP AEVTSTSQSP HSPDSSQSSL AQEEEEEDQG RTRKRKQSGH SPARAGKQRM KEKEQENERK VAQLAEENER LKQEIERLTR EVEATRRALI DRMVNLHQA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards