Protein DEK (DEK)

About Protein DEK

Protein DEK (DEK) is a protein from Homo sapiens identified by UniProt accession P35659, 375 residues long. MolForge cross-references it against 0 known binders and 223 disease associations.

Target properties

Protein name	Protein DEK
UniProt accession	P35659
Gene	DEK
Organism	Homo sapiens
Length	375 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (223)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.41
gastric carcinoma · score 0.37
carcinoma of liver and intrahepatic biliary tract · score 0.37
bile duct carcinoma · score 0.37
Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation · score 0.37
Endometrial Endometrioid Adenocarcinoma · score 0.37
kidney neoplasm · score 0.37
breast ductal adenocarcinoma · score 0.37
gliomatosis cerebri · score 0.37
PR interval · score 0.35

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P35659-F1	alphafold	PREDICTED	65.64	—

Amino-acid sequence (375 residues)

MSASAPAAEG EGTPTQPASE KEPEMPGPRE ESEEEEDEDD EEEEEEEKEK SLIVEGKREK KKVERLTMQV SSLQREPFTI AQGKGQKLCE IERIHFFLSK KKTDELRNLH KLLYNRPGTV SSLKKNVGQF SGFPFEKGSV QYKKKEEMLK KFRNAMLKSI CEVLDLERSG VNSELVKRIL NFLMHPKPSG KPLPKSKKTC SKGSKKERNS SGMARKAKRT KCPEILSDES SSDEDEKKNK EESSDDEDKE SEEEPPKKTA KREKPKQKAT SKSKKSVKSA NVKKADSSTT KKNQNSSKKE SESEDSSDDE PLIKKLKKPP TDEELKETIK KLLASANLEE VTMKQICKKV YENYPTYDLT ERKDFIKTTV KELIS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards