About Cylicin-1
Cylicin-1 (CYLC1) is a protein
from Homo sapiens identified by UniProt accession
P35663, 651 residues long.
MolForge cross-references it against 0 known binders and
82 disease associations.
Target properties
| Protein name | Cylicin-1 |
|---|
| UniProt accession | P35663 |
|---|
| Gene | CYLC1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 651 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (82)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- spermatogenic failure 72 · score 0.08
- spermatogenic failure 20 · score 0.08
- spermatogenic failure 18 · score 0.08
- spermatogenic failure 27 · score 0.08
- spermatogenic failure 46 · score 0.08
- spermatogenic failure 42 · score 0.08
- spermatogenic failure 51 · score 0.08
- spermatogenic failure, X-linked, 3 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P35663-F1 | alphafold | PREDICTED | 45.53 | — |
Amino-acid sequence (651 residues)
MSLPRLLKVN IRTYDNSIPI SESSRKSWNQ KHFALTFPKP LQRGTNDKSR PLKSQITVTR HDKRKLEEGQ KPAHKWIRHS FRKILQWPPI YTAAREQTPF RHLYTSKTHL KKAEYKKSKD EKGGTPLKKD SKKKGGSYAT NPESKQIVEE KTKRQNEADK TPLKSSHENE QSKKSKSSSE TNPESQNSKT VSKNCSQKDK KDSKNSKKTN TEFLHTKNNP KKDLKRSKTS NDPISEICSE NSLNVDFLML VGQSDDESIN FDAWLRNYSQ NNSKNYSLKY TKYTKKDTKK NAKKSSDAES EDSKDAKKDS KKVKKNVKKD DKKKDVKKDT ESTDAESGDS KDERKDTKKD KKKLKKDDKK KDTKKYPEST DTESGDAKDA RNDSRNLKKA SKNDDKKKDA KKITFSTDSE SELESKESQK DEKKDKKDSK TDNKKSVKND EESTDADSEP KGDSKKGKKD EKKGKKDSKK DDKKKDAKKN AESTEMESDL ELKKDKKHSK EKKGSKKDIK KDARKDTEST DAEFDESSKT GFKTSTKIKG SDTESEESLY KPGAKKKIDE SDGTSANSKM EGLESKRGFR MSSKKTTFNE KGEKASTGRV PPSREKPPLP ACEPSLPSPK VRRLCWCKMP PPPPKPRYAP LPEAPWIHKL L
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