About Hepatocyte nuclear factor 1-beta
Hepatocyte nuclear factor 1-beta (HNF1B) is a protein
from Homo sapiens identified by UniProt accession
P35680, 557 residues long.
MolForge cross-references it against 0 known binders and
474 disease associations.
Target properties
| Protein name | Hepatocyte nuclear factor 1-beta |
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| UniProt accession | P35680 |
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| Gene | HNF1B |
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| Organism | Homo sapiens |
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| Length | 557 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (474)
Diseases linked to this target (Open Targets).
- renal cysts and diabetes syndrome · score 0.85
- type 2 diabetes mellitus · score 0.77
- maturity-onset diabetes of the young · score 0.69
- MODY · score 0.60
- nonpapillary renal cell carcinoma · score 0.55
- renal cell carcinoma · score 0.52
- neurodegenerative disease · score 0.49
- transient neonatal diabetes mellitus · score 0.46
- Hyperechogenic kidneys · score 0.45
- hyperuricemic nephropathy, familial juvenile type 3 · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P35680-F1 | alphafold | PREDICTED | 60.72 | — |
Amino-acid sequence (557 residues)
MVSKLTSLQQ ELLSALLSSG VTKEVLVQAL EELLPSPNFG VKLETLPLSP GSGAEPDTKP VFHTLTNGHA KGRLSGDEGS EDGDDYDTPP ILKELQALNT EEAAEQRAEV DRMLSEDPWR AAKMIKGYMQ QHNIPQREVV DVTGLNQSHL SQHLNKGTPM KTQKRAALYT WYVRKQREIL RQFNQTVQSS GNMTDKSSQD QLLFLFPEFS QQSHGPGQSD DACSEPTNKK MRRNRFKWGP ASQQILYQAY DRQKNPSKEE REALVEECNR AECLQRGVSP SKAHGLGSNL VTEVRVYNWF ANRRKEEAFR QKLAMDAYSS NQTHSLNPLL SHGSPHHQPS SSPPNKLSGV RYSQQGNNEI TSSSTISHHG NSAMVTSQSV LQQVSPASLD PGHNLLSPDG KMISVSGGGL PPVSTLTNIH SLSHHNPQQS QNLIMTPLSG VMAIAQSLNT SQAQSVPVIN SVAGSLAALQ PVQFSQQLHS PHQQPLMQQS PGSHMAQQPF MAAVTQLQNS HMYAHKQEPP QYSHTSRFPS AMVVTDTSSI STLTNMSSSK QCPLQAW
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