Glutaredoxin-1 (GLRX)

About Glutaredoxin-1

Glutaredoxin-1 (GLRX) is a protein from Homo sapiens identified by UniProt accession P35754, 106 residues long. MolForge cross-references it against 0 known binders and 222 disease associations.

Target properties

Protein name	Glutaredoxin-1
UniProt accession	P35754
Gene	GLRX
Organism	Homo sapiens
Length	106 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (222)

Diseases linked to this target (Open Targets).

reticulocyte count · score 0.50
Immature Reticulocyte Fraction Measurement · score 0.44
reticulocyte measurement · score 0.33
diffuse plaque measurement · score 0.31
hemolysis · score 0.25
adolescent idiopathic scoliosis · score 0.23
drug use measurement · score 0.20
HbA1c measurement · score 0.20
mean corpuscular hemoglobin concentration · score 0.17
mean corpuscular volume · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P35754-F1	alphafold	PREDICTED	97.06	—

Amino-acid sequence (106 residues)

MAQEFVNCKI QPGKVVVFIK PTCPYCRRAQ EILSQLPIKQ GLLEFVDITA TNHTNEIQDY LQQLTGARTV PRVFIGKDCI GGCSDLVSLQ QSGELLTRLK QIGALQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards