Choline kinase alpha (CHKA)

About Choline kinase alpha

Choline kinase alpha (CHKA) is a protein from Homo sapiens identified by UniProt accession P35790, 457 residues long. MolForge cross-references it against 0 known binders and 238 disease associations.

Target properties

Protein name	Choline kinase alpha
UniProt accession	P35790
Gene	CHKA
Organism	Homo sapiens
Length	457 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (238)

Diseases linked to this target (Open Targets).

neurodevelopmental disorder with microcephaly, movement abnormalities, and seizures · score 0.65
Microcephaly · score 0.60
Seizure · score 0.60
Global developmental delay · score 0.50
Intellectual disability · score 0.50
Abnormal muscle tone · score 0.50
Abnormality of movement · score 0.50
microcephaly · score 0.50
Short stature · score 0.50
neurodegenerative disease · score 0.41

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P35790-F1	alphafold	PREDICTED	82.32	—

Amino-acid sequence (457 residues)

MKTKFCTGGE AEPSPLGLLL SCGSGSAAPA PGVGQQRDAA SDLESKQLGG QQPPLALPPP PPLPLPLPLP QPPPPQPPAD EQPEPRTRRR AYLWCKEFLP GAWRGLREDE FHISVIRGGL SNMLFQCSLP DTTATLGDEP RKVLLRLYGA ILQMRSCNKE GSEQAQKENE FQGAEAMVLE SVMFAILAER SLGPKLYGIF PQGRLEQFIP SRRLDTEELS LPDISAEIAE KMATFHGMKM PFNKEPKWLF GTMEKYLKEV LRIKFTEESR IKKLHKLLSY NLPLELENLR SLLESTPSPV VFCHNDCQEG NILLLEGREN SEKQKLMLID FEYSSYNYRG FDIGNHFCEW MYDYSYEKYP FFRANIRKYP TKKQQLHFIS SYLPAFQNDF ENLSTEEKSI IKEEMLLEVN RFALASHFLW GLWSIVQAKI SSIEFGYMDY AQARFDAYFH QKRKLGV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards