About Protein phosphatase 1A
Protein phosphatase 1A (PPM1A) is a protein
from Homo sapiens identified by UniProt accession
P35813, 382 residues long.
MolForge cross-references it against 0 known binders and
127 disease associations.
Target properties
| Protein name | Protein phosphatase 1A |
|---|
| UniProt accession | P35813 |
|---|
| Gene | PPM1A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 382 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (127)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- hair color · score 0.31
- breast adenocarcinoma · score 0.28
- urate measurement · score 0.27
- diastolic blood pressure · score 0.26
- hair colour measurement · score 0.25
- uric acid measurement · score 0.24
- endometrial cancer · score 0.18
- hepatocellular carcinoma · score 0.10
- cup-to-disc ratio measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P35813-F1 | alphafold | PREDICTED | 94.52 | — |
Amino-acid sequence (382 residues)
MGAFLDKPKM EKHNAQGQGN GLRYGLSSMQ GWRVEMEDAH TAVIGLPSGL ESWSFFAVYD GHAGSQVAKY CCEHLLDHIT NNQDFKGSAG APSVENVKNG IRTGFLEIDE HMRVMSEKKH GADRSGSTAV GVLISPQHTY FINCGDSRGL LCRNRKVHFF TQDHKPSNPL EKERIQNAGG SVMIQRVNGS LAVSRALGDF DYKCVHGKGP TEQLVSPEPE VHDIERSEED DQFIILACDG IWDVMGNEEL CDFVRSRLEV TDDLEKVCNE VVDTCLYKGS RDNMSVILIC FPNAPKVSPE AVKKEAELDK YLECRVEEII KKQGEGVPDL VHVMRTLASE NIPSLPPGGE LASKRNVIEA VYNRLNPYKN DDTDSTSTDD MW
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