About Insulin-like growth factor-binding protein complex acid labile subunit
Insulin-like growth factor-binding protein complex acid labile subunit (IGFALS) is a protein
from Homo sapiens identified by UniProt accession
P35858, 605 residues long.
MolForge cross-references it against 0 known binders and
149 disease associations.
Target properties
| Protein name | Insulin-like growth factor-binding protein complex acid labile subunit |
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| UniProt accession | P35858 |
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| Gene | IGFALS |
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| Organism | Homo sapiens |
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| Length | 605 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (149)
Diseases linked to this target (Open Targets).
- short stature due to primary acid-labile subunit deficiency · score 0.76
- IGF-1 measurement · score 0.66
- lean body mass · score 0.57
- body weights and measures · score 0.50
- whole body water mass · score 0.50
- Reduced insulin like growth factor binding protein acid labile subunit concentration · score 0.50
- anthropometric measurement · score 0.48
- sitting height measurement · score 0.46
- Abnormality of the skeletal system · score 0.45
- base metabolic rate measurement · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P35858-F1 | alphafold | PREDICTED | 90.55 | — |
Amino-acid sequence (605 residues)
MALRKGGLAL ALLLLSWVAL GPRSLEGADP GTPGEAEGPA CPAACVCSYD DDADELSVFC SSRNLTRLPD GVPGGTQALW LDGNNLSSVP PAAFQNLSSL GFLNLQGGQL GSLEPQALLG LENLCHLHLE RNQLRSLALG TFAHTPALAS LGLSNNRLSR LEDGLFEGLG SLWDLNLGWN SLAVLPDAAF RGLGSLRELV LAGNRLAYLQ PALFSGLAEL RELDLSRNAL RAIKANVFVQ LPRLQKLYLD RNLIAAVAPG AFLGLKALRW LDLSHNRVAG LLEDTFPGLL GLRVLRLSHN AIASLRPRTF KDLHFLEELQ LGHNRIRQLA ERSFEGLGQL EVLTLDHNQL QEVKAGAFLG LTNVAVMNLS GNCLRNLPEQ VFRGLGKLHS LHLEGSCLGR IRPHTFTGLS GLRRLFLKDN GLVGIEEQSL WGLAELLELD LTSNQLTHLP HRLFQGLGKL EYLLLSRNRL AELPADALGP LQRAFWLDVS HNRLEALPNS LLAPLGRLRY LSLRNNSLRT FTPQPPGLER LWLEGNPWDC GCPLKALRDF ALQNPSAVPR FVQAICEGDD CQPPAYTYNN ITCASPPEVV GLDLRDLSEA HFAPC
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