Keratin, type I cytoskeletal 20 (KRT20)

About Keratin, type I cytoskeletal 20

Keratin, type I cytoskeletal 20 (KRT20) is a protein from Homo sapiens identified by UniProt accession P35900, 424 residues long. MolForge cross-references it against 0 known binders and 256 disease associations.

Target properties

Protein name	Keratin, type I cytoskeletal 20
UniProt accession	P35900
Gene	KRT20
Organism	Homo sapiens
Length	424 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (256)

Diseases linked to this target (Open Targets).

pancreatic adenocarcinoma · score 0.19
glioblastoma multiforme · score 0.19
breast adenocarcinoma · score 0.18
low grade glioma · score 0.11
neoplasm · score 0.10
Barrett's esophagus · score 0.09
head and neck squamous cell carcinoma · score 0.07
colorectal carcinoma · score 0.07
Merkel cell skin cancer · score 0.06
esophageal adenocarcinoma · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P35900-F1	alphafold	PREDICTED	79.24	—

Amino-acid sequence (424 residues)

MDFSRRSFHR SLSSSLQAPV VSTVGMQRLG TTPSVYGGAG GRGIRISNSR HTVNYGSDLT GGGDLFVGNE KMAMQNLNDR LASYLEKVRT LEQSNSKLEV QIKQWYETNA PRAGRDYSAY YRQIEELRSQ IKDAQLQNAR CVLQIDNAKL AAEDFRLKYE TERGIRLTVE ADLQGLNKVF DDLTLHKTDL EIQIEELNKD LALLKKEHQE EVDGLHKHLG NTVNVEVDAA PGLNLGVIMN EMRQKYEVMA QKNLQEAKEQ FERQTAVLQQ QVTVNTEELK GTEVQLTELR RTSQSLEIEL QSHLSMKESL EHTLEETKAR YSSQLANLQS LLSSLEAQLM QIRSNMERQN NEYHILLDIK TRLEQEIATY RRLLEGEDVK TTEYQLSTLE ERDIKKTRKI KTVVQEVVDG KVVSSEVKEV EENI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards