About Keratin, type II cytoskeletal 2 epidermal
Keratin, type II cytoskeletal 2 epidermal (KRT2) is a protein
from Homo sapiens identified by UniProt accession
P35908, 639 residues long.
MolForge cross-references it against 0 known binders and
236 disease associations.
Target properties
| Protein name | Keratin, type II cytoskeletal 2 epidermal |
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| UniProt accession | P35908 |
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| Gene | KRT2 |
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| Organism | Homo sapiens |
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| Length | 639 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (236)
Diseases linked to this target (Open Targets).
- superficial epidermolytic ichthyosis · score 0.80
- exfoliative ichthyosis · score 0.35
- eosinophil count · score 0.21
- genetic disorder · score 0.19
- head and neck squamous cell carcinoma · score 0.19
- clear cell renal carcinoma · score 0.18
- glioblastoma multiforme · score 0.18
- ovarian cancer · score 0.18
- breast adenocarcinoma · score 0.18
- esophageal cancer · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P35908-F1 | alphafold | PREDICTED | 63.75 | — |
Amino-acid sequence (639 residues)
MSCQISCKSR GRGGGGGGFR GFSSGSAVVS GGSRRSTSSF SCLSRHGGGG GGFGGGGFGS RSLVGLGGTK SISISVAGGG GGFGAAGGFG GRGGGFGGGS SFGGGSGFSG GGFGGGGFGG GRFGGFGGPG GVGGLGGPGG FGPGGYPGGI HEVSVNQSLL QPLNVKVDPE IQNVKAQERE QIKTLNNKFA SFIDKVRFLE QQNQVLQTKW ELLQQMNVGT RPINLEPIFQ GYIDSLKRYL DGLTAERTSQ NSELNNMQDL VEDYKKKYED EINKRTAAEN DFVTLKKDVD NAYMIKVELQ SKVDLLNQEI EFLKVLYDAE ISQIHQSVTD TNVILSMDNS RNLDLDSIIA EVKAQYEEIA QRSKEEAEAL YHSKYEELQV TVGRHGDSLK EIKIEISELN RVIQRLQGEI AHVKKQCKNV QDAIADAEQR GEHALKDARN KLNDLEEALQ QAKEDLARLL RDYQELMNVK LALDVEIATY RKLLEGEECR MSGDLSSNVT VSVTSSTISS NVASKAAFGG SGGRGSSSGG GYSSGSSSYG SGGRQSGSRG GSGGGGSISG GGYGSGGGSG GRYGSGGGSK GGSISGGGYG SGGGKHSSGG GSRGGSSSGG GYGSGGGGSS SVKGSSGEAF GSSVTFSFR
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