About Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (PDE6B) is a protein
from Homo sapiens identified by UniProt accession
P35913, 854 residues long.
MolForge cross-references it against 0 known binders and
442 disease associations.
Target properties
| Protein name | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta |
|---|
| UniProt accession | P35913 |
|---|
| Gene | PDE6B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 854 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (442)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa · score 0.73
- congenital stationary night blindness · score 0.67
- Retinal dystrophy · score 0.57
- coronary artery disease · score 0.55
- stroke · score 0.55
- autosomal recessive retinitis pigmentosa · score 0.49
- Hepatitis, Alcoholic · score 0.48
- Cone rod dystrophy · score 0.48
- diabetic nephropathy · score 0.47
- chronic kidney disease · score 0.47
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P35913-F1 | alphafold | PREDICTED | 89.31 | — |
Amino-acid sequence (854 residues)
MSLSEEQARS FLDQNPDFAR QYFGKKLSPE NVAAACEDGC PPDCDSLRDL CQVEESTALL ELVQDMQESI NMERVVFKVL RRLCTLLQAD RCSLFMYRQR NGVAELATRL FSVQPDSVLE DCLVPPDSEI VFPLDIGVVG HVAQTKKMVN VEDVAECPHF SSFADELTDY KTKNMLATPI MNGKDVVAVI MAVNKLNGPF FTSEDEDVFL KYLNFATLYL KIYHLSYLHN CETRRGQVLL WSANKVFEEL TDIERQFHKA FYTVRAYLNC ERYSVGLLDM TKEKEFFDVW SVLMGESQPY SGPRTPDGRE IVFYKVIDYV LHGKEEIKVI PTPSADHWAL ASGLPSYVAE SGFICNIMNA SADEMFKFQE GALDDSGWLI KNVLSMPIVN KKEEIVGVAT FYNRKDGKPF DEQDEVLMES LTQFLGWSVM NTDTYDKMNK LENRKDIAQD MVLYHVKCDR DEIQLILPTR ARLGKEPADC DEDELGEILK EELPGPTTFD IYEFHFSDLE CTELDLVKCG IQMYYELGVV RKFQIPQEVL VRFLFSISKG YRRITYHNWR HGFNVAQTMF TLLMTGKLKS YYTDLEAFAM VTAGLCHDID HRGTNNLYQM KSQNPLAKLH GSSILERHHL EFGKFLLSEE TLNIYQNLNR RQHEHVIHLM DIAIIATDLA LYFKKRAMFQ KIVDESKNYQ DKKSWVEYLS LETTRKEIVM AMMMTACDLS AITKPWEVQS KVALLVAAEF WEQGDLERTV LDQQPIPMMD RNKAAELPKL QVGFIDFVCT FVYKEFSRFH EEILPMFDRL QNNRKEWKAL ADEYEAKVKA LEEKEEEERV AAKKVGTEIC NGGPAPKSST CCIL
Explore Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets